Overall, aside from potential hypersensitivity, there are no absolute contraindications to biotin therapy on record
For a more detailed background, you can refer to upcoming resources on what peptide therapy is (article pending publication)
Each method has its own pros, cons, and suitability depending on your lifestyle and skin goals
The peer-reviewed record contains no dose pair, no titration schedule, no tolerability data and no efficacy figure for the combination
The GST tag can easily be removed following purification by addition of a protease if a suitable protease-cleavage site has been inserted between the GST-tag and the protein of interest (which is usually included in many commercially available sources of GST-tagged plasmids)
Zero adverse events (Kuceki et al., 2025)