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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
In experimental rat models, it has been determined that the seizures in animals did not recur for a long time with the administration of some antioxidant agents in animals with epilepsy 47
Immunosenescence and Inflammaging: risk factors of severe COVID-19 in older people
Regular B12 injections can improve focus and mood, helping you feel more balanced throughout the day
Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension
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