Am J Geriatr Pharmacother
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Losartan pretreatment increases the glimepiride hypoglycemic effect by increasing insulin sensitivity as well as progressing insulin homeostasis, which could be attributable to CYP2C9 suppression.[] Furthermore, oral administration of losartan to diabetic induced rats improved insulin sensitivity, resulting in lower fasting and fed glucose levels.[] Hypoglycemic losartan activity may be due both to insulin resistance and reduced hepatic glucose consumption in both normal and diabetic rats as previously established.[] According to Chu et al.'s findings, AT1 receptor antagonists improve the glucose tolerance and -cells function in juvenile type 2 diabetic mice.[] Furthermore, oral losartan therapy to diabetic rats has been found for increasing insulin sensitivity, resulting in lower fasting along with fed glucose concentrations.[] Studies showed that Losartan in people with type 2 diabetes and nephropathy, enhances insulin sensitivity, improves -cell response to glucose, as well as augment glucose homeostasis.[] Conclusion Losartan along with glimepiride and metformin combination was significantly associated with lowering the glucose level in both nondiabetic and diabetic rats and rabbits
