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Promising interventional approaches include the oral administration of live probiotics or purified bioactive metabolites, either as monotherapies or in combination with conventional anticancer agents, to potentially impede colorectal carcinogenesis (303)

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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

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