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Indeed, while SCFAs infused into the intestinal lumen activate VANs projecting from the gut 12 and intraperitoneal SCFA injection suppressed food intake through vagal afferent signaling, butyrate treatment directly activates isolated nodose ganglion neurons from mice 12

It could be cancer destroying healthy cells and releasing B12 back to the blood, a bad liver that can no longer store B12, or an increased production of the transport protein haptocorrin, to which blood B12 binds

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