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For comparison, tirzepatide (Mounjaro, Zepbound) has a slightly lower constipation rate at 14-17% across doses, possibly because the GIP receptor component partially counteracts GLP-1's motility effects in some patients
10.1155/2020/1516493 35 GameilM
Less common but notable skin reactions may include nodules or small lumps under the skin, particularly if injection sites are not rotated adequately
Some formulations include lidocaine to reduce discomfort
Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells
Scirica, a professor of medicine at Harvard Medical School, said the findings were "surprising." "The fact that semaglutide reduced non-cardiovascular death, and in particular COVID-19-related deaths, was surprising
