2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)
Ivanov, A
doi: 10.1038/425037a 12 DurrantWEDongX
For these reasons, I rated it a 2 out of 5
Non-Responders (5-15% of users): See minimal or no improvement despite consistent dosing
With nine generic semaglutide applications under Health Canada review, Novo Nordisk is clearly trying to lock in patients before cheaper alternatives arrive and they're willing to slash prices dramatically to do it