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Peptide therapy vs IV drips and other treatments Peptide therapy vs IV drip therapy -peptides are typically injected or applied topically and work over time

- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

The key point: capsules are easier, but injections may be more direct

This channel is the one directly affected by the Category 1/Category 2 decision

FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture

This contraindication is absolute and applies regardless of dose