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Some GLP-1 medications have demonstrated cardiovascular protective effects in specific populationsliraglutide, semaglutide injection, and dulaglutide have shown cardiovascular outcome benefits, with Wegovy (semaglutide) recently receiving an FDA indication for cardiovascular risk reduction in adults with established cardiovascular disease and either overweight or obesity
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For off label weight loss use in non diabetic patients, most commercial insurance plans deny coverage
Frontiers in Endocrinology, [online] 15
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![Structure of [ 3 H]liraglutide (top) and the GLP-1 receptor agonists](https://www.researchgate.net/profile/Inga-Bjornsdottir-2/publication/45650716/figure/fig2/AS:667822585806848@1536232720030/Structure-of-3-Hliraglutide-top-and-the-GLP-1-receptor-agonists-liraglutide-and.png)
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