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Initially identified as a secreted factor induced by exercise and cold exposure, METRNL promotes energy expenditure and improves glucose tolerance through mechanisms involving immuneadipose crosstalk and beige adipocyte activation (Rao et al., 2014)

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We observed that addition of electron-withdrawing substituents on the phenyl ring increased the electrophilicity of the chloroacetamide carbon and improved potency of inhibition (Supplementary Table 1)

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Differential behavioral and biochemical responses to caffeine in male and female rats from a validated model of attention deficit and hyperactivity disorder

The peptide's tissue remodeling effects continue even after discontinuation