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Jastreboff et al., NEJM 2023)

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PAC1R, VPAC1R, and VPAC2R) have been identified, and they can activate diverse pathways, including the signaling through AC (169)

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Effects of creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skinA pilot clinical, histologic, and ultrastructural study

This central action provides a strong basis for its role in neuroprotection against biochemical insults and stress