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It is released immediately after you eat to signal to your body that fuel has arrived
It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue
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Besides, similar dose-response characteristics between GLP-1 and compound 2 suggest that the latter is capable of stimulating GLP-1R independently (ago-allosteric activation)
Triple agonists that target GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors are now in clinical testing
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