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Information & Authors Information Published In Copyright Circulation: Arrhythmia and Electrophysiology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc
Dehydration is one of the biggest concerns with semaglutide and other GLP-1 drugs, and also one of the most dangerous potential side effects
GLP-1 Key Research Facts Full name: Glucagon-Like Peptide-1 incretin hormone of the proglucagon family Primary bioactive form: GLP-1(736)amide 30 amino acids, C-terminally amidated Gene source: Proglucagon gene processed by PCSK1 in intestinal L-cells and brainstem NTS neurons In vivo half-life: Approximately 12 minutes rapidly inactivated by DPP-4 (cleaves His7-Ala8 dipeptide) Primary receptor: GLP-1R (GLP-1 receptor) class B G protein-coupled receptor (GPCR) Signalling: GLP-1R activation cAMP elevation PKA/CREB activation glucose-dependent insulin secretion Additional signalling: PI3K/Akt pathway -cell survival, proliferation, and glucose sensitivity Secretion pattern: Biphasic post-meal release from intestinal L-cells early neural/endocrine peak + late direct nutrient-contact peak Fasting plasma level: ~510 pmol/L
Fatigue is reported to be more common with higher doses of semaglutide, such as those used in Wegovy, compared to lower doses like Ozempic
192,193 Although the nature of the relationship is not entirely understood, it is believed that smoking causes blood vessel damage and dysfunction that leads to poor kidney blood flow and decreased kidney function
