They are popularly used to treat type 2 diabetes mellitus (T2DM) and obesity
Adipose-selective fat metabolism
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Acidosis is due to reduced feedback inhibition of -glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline
However, its important to be aware of possible reactions, 3 including: Common side effects : Nausea, vomiting, diarrhea, constipation, stomach pain Less common but serious risks : Severe gastrointestinal reaction, pancreatitis, acute kidney injury, hypoglycemia (especially if taken with insulin), visions changes (i.e., decreased/blurred vision), mental mood changes (i.e., depression, thoughts of suicide)
Patients comparing Zepbound vs Ozempic often face similar considerations, reinforcing the importance of individualized selection rather than ranking medications universally