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Crohn's disease and ulcerative colitis, including exacerbations, have occurred during treatment with this medicine

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The basic layering rule Thinnest to thickest consistency: Cleanser Toner (if using) Thinnest serum (usually peptide serum) Retinol (if in serum form) Moisturizer Occlusive (if needed) Why this order: Thinner products penetrate better when applied first