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J Biol Chem 265, 2025920262 (1990)
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That flat selectivity profile is precisely what keeps MT2 useful in vitro: it serves as the positive-control full agonist against which subtype-selective ligands are benchmarked, and it is the parent scaffold for a large derivative family generated by single substitutions at positions 6, 7 and 9, including the MC3R/MC4R antagonist SHU-9119
Additionally, people who are more sensitive to changes in gastric motility, and those on higher medication doses, may be more prone
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