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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]
Rab A, Rowe SM, Raju SV, Bebok Z, Matalon S, Collawn JF
Although the NPY modulation has been explored in obesity, alcoholism, anxiety, depression, epilepsy and pain (reviewed in [34, 182, 183]), its potential benefit in asthma is largely unknown and unexplored
This reduced risk of acute exacerbations and pulmonary-related mortality is also seen in patients with COPD [91, 92]
