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Quick Clinical Advice Monitoring Rule: Track liver function tests (ALT/AST) and serum bile acid levels periodically, as NTCP receptor inhibition can transiently elevate circulating total bile salts
The B12 deficiency itself getting worse, either because not enough unhealthy red blood cells have expired and been replaced by healthy ones (each one of them has a 90 day life-cycle), or because the B12 wasnt injected on a daily schedule
*Oxidative Medicine and Cellular Longevity.* 2012;2012:324832
It loads the gun, but UV exposure pulls the trigger
Elevated cAMP levels subsequently activate protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (RAPGEF4, also known as EPAC2)
Baseline assessment should include fasting IGF-1, growth hormone, cortisol, prolactin, and complete metabolic panel
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