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How Semaglutide Might Raise Your Heart Rate Semaglutide is a glucagon-like peptide-1 receptor agonist that acts on multiple tissues

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While sitagliptin and exendin-4 significantly increase plasma insulin levels 5-min post injection, these levels are not significantly different from PBS control after 20 min, suggesting that the GLP-1 mediated reduction in intestinal-TG secretion is independent of the incretin effect

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