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PDA risk in short-term insulin use (less than 3 years) is significantly increased, while people who started insulin more than 5 years showed a relatively lower risk (0.50.7 folds) than new starters (Li et al., 2009

Proliferation of human hematopoietic progenitors in long-term bone marrow cultures in gas-permeable plastic bags is enhanced by colony-stimulating factors

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Estrogen decline affects appetite centers in the hypothalamus, reducing satiety signals and increasing hunger hormones such as ghrelin

Hormone signaling, stomach motility, and nervous system sensitivity vary widely