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The research specifically shows that stressing out rats with mild stressors for 40 days causes increases in oxidative stress, including increases in SOD (superoxide dismutase).[ref] (We will return to SOD in a minute.) How does the dysregulation of the HPA axis and altered cortisol levels cause mitochondrial dysfunction

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However, with in vitro patch clamp recording, direct application of acetaminophen to the spinal cord did not change miniature EPSCs (mEPSCs), but AM404 did