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Some clinicians prescribe it off-label for weight loss, but expected results are more modest than the injection

Reasons to track liver enzymes while on GLP-1s: Rapid fat mobilization during weight loss can temporarily affect liver function Pre-existing fatty liver may improve, and testing confirms progress Dehydration from reduced appetite can concentrate liver enzymes Combining GLP-1s with other medications increases liver processing demands Some individuals experience transient enzyme elevations that resolve with time If you're already monitoring pancreatic enzymes like amylase and lipase on GLP-1 therapy, adding liver markers gives you a complete picture of how your body is responding

In 2021, the injectable form of semaglutide (Wegovy) was approved for treating obesity

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