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Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)
This guide covers physiology, practical support strategies, and how endogenous incretin signaling differs from prescription receptor agonistswithout turning lifestyle tips into medical advice
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For Ozempic or Wegovy: You inject it once weekly on the same day each week You can take it any time of day, with or without food No waiting period or special instructions This flexibility is why some people end up preferring the injection despite initial hesitation about needles
doi: 10.1111/j.1365-2567.2009.03225.x 75 SPLanaAJ
USA 119 (13), e2116506119 (2022) A
