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A major extracellular enzyme, GPX3, is also found in the cytoplasm and plasma membranes of the mammalian kidney, epididymis, heart, lung, liver, brain, adipose tissue, mammary gland, and gastrointestinal tract (Nirgude and Choudhary, 2021)

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It develops when the peripheral nerves, which are located outside of the brain and spinal cord, are damaged