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Trib1 D355 makes a salt bridge with COP1 K472 and Trib1 Y361 forms a hydrogen bonding with COP1 H578 (Fig
In the only trial that directly compared the two so far (REDEFINE 4), Mounjaro produced slightly more weight loss than CagriSema (25.5% vs 23.0% over 84 weeks), and CagriSema didnt meet the trials main goal