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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 9, 37
Skin Sensitivity: Mild redness and irritation may occur after treatment, but usually resolves in a short time
In the Phase 2 paper there was no clear depression signal, but a letter to the editor in The Lancet noted that the trial excluded patients with psychiatric histories, which makes the safety estimate look better than it might be in a general population
Given trial heterogeneity (doses, agents, durations), individualization, monitoring, lifestyle support, and collaboration with hepatology are key
In August 2025, a review found that flavonoids, which contribute to bitter flavors in, say, citrus or hops, can stimulate GLP-1 release, too
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