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Notwithstanding progress in diabetic retinopathy treatments, such as laser photocoagulation, intravitreal anti-VEGF therapy, and corticosteroids, treatment is constrained by exorbitant costs, intrusive techniques, unpleasant effects, and inconsistent patient responses

Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well

Also, unhealthy fats can directly cause weight gain by accumulating in the body and visceral region

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Hepatology 2002