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Body aches should be assessed if they are severe, persistent, associated with fever, muscle weakness, dark urine, chest pain or feeling very unwell

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Call for severe vomiting, signs of dehydration, or intense abdominal pain

Common side effects are gastrointestinal (nausea, diarrhoea, vomiting) and typically occur during initial treatment or dose increases

We need to bridge the gap between this robust trial evidence and everyday clinical practice to improve long-term patient outcomes

The typical adult dosage is 0.25 mL to 2 mL per dose, depending on the severity of the deficiency or the clinical indication