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70 For example, compound 2j, a triazole-containing derivative, has demonstrated high potency and comparable efficacy to danuglipron in preclinical studies, suggesting it could serve as a lead compound for further development

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Clinical studies highlight its effectiveness in obesity management, with weight reduction of 611% of body weight achieved over 20 weeks when administered weekly ( 1, 2 )

Lancet (2017) 389:1399409

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Methionine's half-life in plasma is approximately 2.5 hours, but its functional duration as a methyl donor extends 4872 hours because SAMe persists in hepatocytes after the parent amino acid clears circulation