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The reduction in muscle cross-sectional area without any reduction in strength likely reflects loss of intramuscular substrate (triglycerides, glycogen) rather than contractile proteins

PMID: 35775116

The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation

Archived from the original on 25 December 2019

I had a young patient come in whos struggling with obesity and he said, Doc, I dont have time to go to the gym

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