In vitro and in vivo experiments in OA, RA and psoriasis models have demonstrated weight-loss-independent anti-inflammatory and chondroprotective effects of GLP-1RAs, commonly through inhibition of the NF-B pathway
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Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study
The evaluation resulted in three very-low quality evidence of TG, HDL, and uric acid