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Du X, et al
Nature 440 , 237241 (2006)
The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11
Overnutrition, a form of malnutrition where nutrients, specifically macronutrients, are provided in excess of dietary requirements, also negatively impacts immune system functions (see Overnutrition and obesity)
However, the safety of long-term use hasnt been established
Cysteine is usually the rate-limiting amino acid, linking glutathione production directly to dietary protein, cysteine availability and transsulfuration
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