Once the first dose is drawn from a vial or the first injection given from a pen, the in-use period begins
Most of these gastrointestinal side effects are mediated through the central nervous system
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However, there are recommendations to help counteract some of the effects GLP-1s have on appetite and digestion
For instance, hunger hormones can overshoot even normal levels, making people feel hungrier than before treatment
In wild-type mice, intraperitoneal CGRP increased auditory brainstem response, reduced vestibular sensory evoked potential amplitudes, and heightened sound-evoked startle and postural sway, which parallels phonophobia and balance issues in vestibular migraine (VM)