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Aliabadi E et al

According to UK guidance, metformin is contraindicated in patients with eGFR below 30 mL/min/1.73m, should not be initiated in those with eGFR 30-44 mL/min/1.73m, and requires dose review/reduction for eGFR 30-59 mL/min/1.73m

Phosphorylation of the Bcl2 family protein Bid can increase apoptosis initiation and sensitivity to mitotic drugs

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However, once youre in a 12-week cycle, there are no refunds for whats left