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Coupling with drugs, fluorescent tracers or various targeting molecules can significantly change the physico-chemical properties and the intracellular fate of the nanocarriers [28, 51]

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However, provided variations in the water content within the sample are much smaller than the variations in the metabolite levels, variance shared between normalized metabolite signals can be assumed to arise largely from shared variance in metabolite concentrations [52]

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In contrast, weight loss improves muscle insulin sensitivity, which, in turn, helps prevent muscle protein breakdown