Sikiric group: extensive rat-model evidence of gastric and intestinal cytoprotection
Semaglutide (Wegovy), approved at a 2.4 mg weekly dose, represents the most potent GLP-1 receptor agonist currently available for weight management
In 2019, nearly 90% of patients initiating therapy were diabetics, but by 2023, their share had dropped to just over 70%
Academic Significance: Though pharmacologic agents developed for improved metabolic outcomes, including GLP-1, are known to affect both metabolic regulation and aging, little research to date has established whether or not GLP-1 receptor agonists such as semaglutide can reduce inflammation and affect biological aging processes (while also reducing weight)
It works a bit differently than traditional GLP-1 medications
Next, we evaluated photocrosslinking between a photoreactive probe (PRP) (a slow inhibitor of TGR, Fig