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, 2021, vol

492 These findings suggest that hyperglycemia is only one of multiple factors contributing to neuropathy in T2DM, highlighting the need for a multifactorial approach to management

doi:10.1074/jbc.M907022199 Mari M, Wu D, Nieto N, Cederbaum AI (2001) CYP2E1-dependent toxicity and up-regulation of antioxidant genes

PTECs are highly sensitive to hyperglycemia ( Hyperglycemia increases the amount of glucose filtered through the glomeruli, thereby increasing tubular glucose load, exposure and reabsorption