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By activating all three receptors, retatrutide is designed to suppress appetite, and preclinical and early-phase data suggest it may also increase energy expenditure and improve metabolic function though robust long-term human evidence for the energy expenditure effect remains limited

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People treated with these drugs can develop gastrointestinal side-effects including diarrhoea, so it is not implausible that some women may find that their oral contraceptive pill is, at least intermittently, not as reliably absorbed as it was previously, he said

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Bahuon, F., Pantazoglou, E., Untracht, G., Andersen, P

PMID: 41966639