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This section will briefly review what we know about the current safety data of GLP-1 and GLP-1/GIP agonists, and factors that may promote long term clinical use of these agents in obesity
Contrave is not appropriate for patients with seizure disorders (bupropion lowers the seizure threshold), eating disorders such as bulimia or anorexia, current opioid use or opioid dependence (naltrexone blocks opioid receptors), uncontrolled hypertension, patients taking MAO inhibitors, or women who are pregnant or planning to become pregnant
GLP-1 and GIP receptor activation improves insulin sensitivity dramatically
17 A recent study found that MAFLD was present in 39% of patients with acute pancreatitis
287 , L332L343 (2004)
Oral antioxidants like glutathione reduce melanogenesis by suppressing these free radicals
