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Hypothesis 2 Smoother appetite curve GLP-1 satiety and amylin satiety are partially out-of-phase amylin signaling is more meal-bound (postprandial), GLP-1 satiety is more sustained

The y-peptide bond is important for not being degraded by most peptidases in the cell, with the exception of GGTs (gamma-glutamyl transferase) (Ohkama-Ohtsu et al

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doi: 10.1093/nar/gku1276 298 JiangHCaoKFanCCuiXMaYLiuJ