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In addition to neural connections, the central clock system also synchronizes the circadian rhythms of the peripheral clock system through hormones or factors, such as arginine vasopressin (AVP) and tumor necrosis factor (TNF) ( FIGURE 1 The clock system mainly regulates metabolism in the following three ways

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Oxidative Medicine and Cellular Longevity , 2012.PMID: 22900128 Review of GHK-Cu as an endogenous tripeptide that declines with age, with evidence for antioxidant, anti-inflammatory, and tissue-remodeling properties