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Avoid Food and Drinks Wait at least 30 minutes before consuming anything other than water (4 ounces or less)
Traditional treatments, such as positive airway pressure (PAP) therapy, have shown variable effectiveness, often hindered by patient adherence issues
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According to the UK SmPC, the most frequently reported adverse effects include: Gastrointestinal side effects (very common, affecting more than 1 in 10 people): Nausea often most pronounced during the initial weeks of treatment or following dose escalation Diarrhoea may be mild to moderate and typically improves with continued use Vomiting can occur, particularly if dietary modifications are not made Constipation less common than diarrhoea but reported in some patients Abdominal pain or discomfort usually transient Decreased appetite a therapeutic effect contributing to weight loss but may be troublesome for some These gastrointestinal symptoms are generally dose-dependent and tend to diminish over time as the body adapts to the medication
Alcohol: The company's provider guides advise limiting or avoiding alcohol during treatment, especially during dose adjustments, as it may worsen nausea, low blood sugar, or dehydration
The glutathione S-transferases: an update
