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Lack of sleep and stress can decrease glutathione levels

This reduction in weight is largely due to the medications effects on appetite regulation, insulin sensitivity, and slower gastric emptying 3,8

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doi: 10.7759/cureus.40948 42 JonesRMMercanteJWNeishAS

In contrast, chronic overnutritionparticularly with hyperglycemia and lipid excessincreases mitochondrial electron pressure and ROS generation, rapidly overwhelming glutathione buffering capacity and accelerating cardiometabolic dysfunction

ACKNOWLEDGMENTS The authors thank David Caprio, Dan LoTurco, Gates Roe, Larry Toft, and Karen Trembler for their technical support