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On average, clinical trials have found that patients on semaglutide (the active ingredient in Ozempic and Wegovy) may lose between 15% to 20% of their body weight within the first year of use

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Both agencies noted that the reports were rare relative to the large number of patients using these medications and that confounding factors, including pre-existing mental health conditions, major lifestyle changes, and concurrent medications, made it difficult to attribute psychiatric symptoms directly to GLP1 treatment

Ghrelin: Structure and function