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Patients with diabetic retinopathy should be monitored according to standard diabetes care guidelines, as rapid improvement in glycemic control has been associated with temporary worsening of retinopathy in some studies, though this is not a tirzepatide-specific labeled warning

The gradual titration schedule used in our program is specifically designed to minimize these effects

However, severe swelling, intense pain, warmth, pus, or signs of injection should be reported to a healthcare provider

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These skin symptoms may appear shortly after starting the medication or develop after several weeks or months

iScience 27 , 109923 (2024)