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The strategy of GLP-1RAs combined with non-pharmacological therapy for improving sarcopenia Given that the weight loss effect induced by GLP-1RAs is often accompanied by the risk of muscle loss, and this influence is regulated by multiple factors such as age, underlying diseases, and the duration of treatment, in order to retain muscle mass to the greatest extent, the clinical consensus suggests that GLP-1RA treatment must be combined with active non-pharmacological intervention

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The trial was conducted according to the principles of the Declaration of Helsinki and Good Clinical Practice guidelines