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Ding B, Zheng P, Jiang F, Zhao Y, Wang M, Chang M, et al

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Autism following a history of newborn encephalopathy: more than a coincidence

In patients with obesity, significant weight reduction achieved with GLP-1 therapy has been associated with improvements in sex hormone-binding globulin (SHBG) levels, reductions in free testosterone in women with hyperandrogenism, and normalization of menstrual cycles in some individuals with polycystic ovary syndrome (PCOS)

see Figure 1 taken from a population-based cohort study of 3.6 million adults in the UK

This two-way influence creates a dynamic loop where diet, microbiome, and behavior all play a role in modulating GLP-1 secretion