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In addition, two human melanoma cell lines A-375 and M14 also obtained dendritic phenotypes after C-3-G treatment

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Conclusions Results of this study indicated that, in contrast to livestock mammals and poultry where creatine synthesis requires the interorgan cooperation of the kidneys and liver but is absent from skeletal muscle, creatine synthesis occurred primarily in skeletal muscles from Phase-I and Phase-II HSB

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Nonetheless, as with all biomarkers, real-world sensitivity and specificity remain context-dependent, and blood-based assays like Lumipulse G are best used as complements, not replacements, to comprehensive clinical assessment