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These simulations indicate that the ECD in the apo-state GLP-1R is quite dynamic and that the TMD-interacting closed conformations are energetically favorable in the absence of the peptide agonist

doi: 10.1016/j.celrep.2019.06.018 42 JhaAKHuangSC-CSergushichevALampropoulouVIvanovaYLoginichevaEet al