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Protein becomes critical

Elevated expression of ER stress markers, including GRP78, ATF-6, X-box binding protein-1, C/EBP homologous protein (CHOP), and phospho-Jun N-terminal kinase (p-JNK), was evident in the hippocampal CA1 of diabetic rats, 68 which may ultimately affect synaptic plasticity

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These properties make PT141 a welldefined reference peptide for studying melanocortin signalling under controlled laboratory conditions.\n\nIn biochemical and cellular research systems, PT141 acts as an agonist at the centrally expressed melanocortin receptors MC3R and MC4R, with comparatively higher potency at MC4R and substantially reduced activity at MC1R relative to Melanotan II

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